ADVANCED CHEMISTRY DEVELOPMENT

ACD/Structure Design Suite




Quickly generates a listof suggested analogs withimproved molecular physical properties through modification of a compound's structure.
"New ideas are always welcome in chemistry"
-ACD/Structure Design Suite User
var swidth=236;
var sheight=171;
slide[0]='images/sds1.png';
url[0]="window.open('images/sds1_.png','','resizable=yes,menubar=yes,status=yes,scrollbars=yes,width=470,height=340')";
slide[1]='images/sds2.png';
url[1]="window.open('images/sds2_.png','','resizable=yes,menubar=yes,status=yes,scrollbars=yes,width=470,height=340')";
slide[2]='images/sds3.png';
url[2]="window.open('images/sds3_.png','','resizable=yes,menubar=yes,status=yes,scrollbars=yes,width=470,height=340')";
slide[3]='images/sds4.png';
url[3]="window.open('images/sds4_.png','','resizable=yes,menubar=yes,status=yes,scrollbars=yes,width=470,height=340')";
Building on our industry standard predictions of physicochemical properties (logP, pKa, logD, and solubility), ACD/Structure Design Suite uses property foresight to suggest substituents to help focus synthetic efforts on analogs with specific physicochemical endpoints.
Physical properties play a key role in determining characteristics of pharmaceuticals such as permeability and solubility; environmental endpoints of agrochemicals and waste chemicals from industrial processes; and in the design and development of novel chemicals.
Structure Design Suite has been specially designed to offer a structured workflow aimed at optimizing properties according to the chemist's synthetic goals. Such goals might include any characteristic of the final synthetic product that relates to the molecular physical properties of the compounds, such as better solubility for pharmaceutical compounds, targeted action in pest species and decreased environmental distribution for agrochemicals, lower absorption for artificial flavors, and much more. Read more about how the application works.
Key capabilities of the software include:
Property optimization of compounds through structural modification
Physicochemical property prediction of all generated analogs for structure activity relationship (SAR) optimization
Powerful graphing tools to allow you to filter results and focus on well-balanced analogs
Customizable viewer that offers a quick snapshot of molecular property profiles (including Rule-of-5 violations) one compound at a time
Ability to extend prediction accuracy to novel/proprietary domains through algorithm training with your own property measurement data
For more resources and detailed information about the software, review the links on the left-hand navigation pane.
To discuss your trial evaluation of this software, please contact sds@acdlabs.com.

DALTON LAB'S

GMP Manufacturing Facility
From April 1986 to April 2000, Dalton Chemical Laboratories, through Innovation York, had the use of 6,000 square feet of synthetic chemistry laboratory and office space at York University.
Experiencing tremendous growth in the late 1990s, Dalton began the search for an off-campus location in close proximity to York University.
In August 1999, 349 Wildcat Road was purchased; this 42,000 square foot building had approximately 7,000 square feet of existing office space and 35,000 square feet of warehouse space.
The building retrofit was designed and engineered by Levine Lauzon Architects and Crossey Engineering Ltd. The building was renovated to accommodate a GMP Synthesis Manufacturer production area, synthetic and analytical laboratories, technical support services as well as technical writing areas and offices.
Construction began in November 1999 and was completed in April 2000.
Renovation History
Phase I:
1999-2000 Research and Analytical laboratories, GMP area, technical and administrative office construction


Phase II:
Spring 2001: Sterile Filling room construction Autoclave and process equipment installation.


Phase III:
Fall/Winter 2003: Bipolymer laboratory, microbiology laboratory construction, QA Sampling area.


Phase IV:
Summer/Fall 2004: Level 6 Controlled Substances room, LC-MS laboratory.


Phase V:
Summer/Fall 2005: Oligo Manufacturing Facility.


Phase VI:
Fall/Winter 2005 - 2006: GMP warehouse, Controlled access Stockroom, Controlled access Stability/Environmental chamber area, Column Preparation room.


Phase VII
Fall/Winter 2007 – 2008: Building Management System including Building Monitoring System, building video security system, expansion of Analytical Laboratory, ICH compliant sample retention area, purification lab, installation of 8 additional fumehoods, 3 rd validated LCMS, 2 nd Dionex
The GMP Manufacturing Facility
As a GMP Synthesis Manufacturer, Dalton’s facility is comprised of the following technical and administrative areas:
GMP Manufacturing and Sterile Filling AreaThe GMP manufacturing facility is approximately 2,500 square feet and includes separate rooms for the following production functions:
Personnel Airlock
Materials/equipment Airlock
GMP Suites (2)
Sterile Filling Room
Autoclave Room
Equipment/Glass Wash Area
Product Storage Room
The environmental conditions within the GMP Manufacturing Facility, including temperature, humidity, air pressure, and air quality are monitored at regular intervals and aseptic conditions are maintained through routine cleaning. The entire GMP Manufacturing Facility is under positive pressure relative to the warehouse and the writing area corridor. Access to the GMP Manufacturing Facility is restricted to authorized personnel and is controlled by an access card system.
GMP SuitesThese rooms were designed for the production of APIs. Each GMP Manufacturing suite is fitted with stainless steel tables, an 8-foot walk-in hood and a 6-foot bench top fume hood. Terminal HEPA filters are located throughout the ceiling to maintain air quality. The walls, ceiling, and floors are finished with a highly durable epoxy based coating to maintain a high level of cleanliness. The manufacturing suites have a Grade C classification.
Sterile Filling AreaA GMP sterile filling area was constructed during Phase II Renovations in Spring 2001. This area is approximately 300 square feet in size and is constructed with an aluminum frame and polypropylene walls and ceilings. The area contains a material air lock, a personnel airlock for gowning and a localized Grade A area for the semi-automated filling machine. There are terminal HEPA filters located in the ceiling and pressure, temperature and humidity are all monitored continuously through Dalton’s Building Automation System. A full environmental monitoring program is in place for this area and for all additional rooms in the GMP area.
Autoclave RoomLocated in the GMP area, this room provides a localized Class A environment for all clean items being removed from the autoclave. The autoclave was installed during Phase II Renovation in the Spring of 2001 along with several pieces of process equipment including a pure steam generator, plant steam boiler and a RO/DI purified water system. The input side of the autoclave is located in the GMP Equipment/Glass Wash Area.
Synthetic LaboratoriesThere are two synthetic production laboratories approximately 1,100 square feet each. Each laboratory has eight bench top fume hoods and one walk-in fume hood. Dalton Chemicals is capable of producing fine chemicals in multi-kilo batches using 22 L, 30 L, 50 L and 100 L glass reactors.
Analytical LaboratoryOur analytical services area was architecturally designed to house a vast array of analytical equipment. Each HPLC, CE, GC, titrators and other pieces of equipment are located for maximum efficiency of space and data communication. The analytical team has the use of bench top fume hoods as required. We have added LC-MS capabilities with our latest addition, an LC-MS laboratory area.
Microbiology Laboratory This 350 square foot laboratory accommodates the necessary staff and equipment to support Dalton’s rigorous environmental monitoring program for the GMP area . The biological safety cabinets and incubators are used for on-site bioburden testing, microbial identification and environmental monitoring of the GMP area.
QA Sampling Room This 100 square foot room has been designed in order to completely segregate the sampling of solvents and other raw materials for GMP. This room features a fume extractor arm and some stainless steel benching for work space. Access to this room is restricted to authorized personnel only.
Laboratory ServicesTo maintain efficiency and safety in the laboratories, separate rooms were developed to accommodate the following activities:
Hydrogenation Room (location of 2 x 2L Parr Reactors)
Solvent Storage and Dispensing
Waste Solvent Storage
Gas Cylinder Storage
Glass Wash and Storage
Retained Sample Storage
These rooms operate under restricted access and have segregated areas for those items used in GMP and Sterile Filling Production.
Facility Amenities
Building Automation System (BAS), which continuously monitors temperature, humidity and pressurization in all laboratory areas. In addition the system monitors the higher hazard areas of solvent storage and the hydrogenation room in case of solvent leak and/or fire.
Security system with proximity card access to critical areas. The GMP facility also has additional security cameras for observation purposes.
Validated USP Purified Water System and Pure Steam Generator
Newly refurbished boardroom, lunch room, and employee locker rooms.
Over 6,000 square feet of technical writing areas, administrative and management offices.
Separate shipping and receiving area located in 18,000 square feet of warehouse and future expansion space.
Facility Vision to 2011
GMP Facility Expansion As a GMP synthesis manufacturer, we are now in the final stages of planning and design of our GMP facility expansion.
We will be adding the following capabilities to our existing GMP Manufacturing and sterile filling operations.
Materials Process & Preparation area This area will be equipped with a high capacity Fedegari autoclave, a large scale Gruenberg pass-through depyrogenation oven, a smaller scale Despatch pass-through depyrogenation oven and a high speed Cozzoli vial washing line coupled with a Bosch/Strunck depyrogenation tunnel.
Sterile Fill Rooms The new facility will contain four new fill rooms each equipped with different filling equipment including a Cozzoli high speed vial filling line, a Cozzoli syringe filler, a Flexicon semi automatic vial filling line and a M&O Perry powder filler.
Formulation Rooms We will be constructing two Formulation rooms equipped with a separate equipment wash and preparation area including Clean-in-place/Steam-in-place capabilities.
Lyophilization This service will be added during the third phase of construction. We are considering a smaller scale and a larger scale unit which would allow us the capability of lyophilizing for R&D and scaling up when necessary.
Label and Clean Packaging Room This room will allow us to properly label and package all of our manufactured goods according to our customers needs.

UNIVESITY OF OXFORD

The Chemical Crystallography Laboratory is located in the basement of the new Chemistry Research Lab on the corner of South Parks Road and Mansfield Road. The laboratory contains state of the art crystallographic diffraction equipment, laboratory space for sample preparation, office space for computational and theoretical work.
The Structure Analysis Service is run by Amber Thompson, who has recently joined us from Judith Howards lab in Durham. Members of other groups within Chemistry are encouraged to do their own structural analyses, and space, computers and patient tuition are available for them in the laboratory.David Watkin's group currently consists of two Post Docs (James Heastier & Mustapha Sadki) and an emeritus professor (Terry Willis).
The Chemical Crystallography Laboratory has a long history of involvement in software development. Our software, CRYSTALS (for single crystal X-ray structure refinement and analysis) is used world wide, and is available free of charge to not-for-profit users.The internal data-structure of CRYSTALS has now (after 30 years) reached its limits, so that major developments to the program have become increasingly difficult. Non the less, minor enhancements and bug-fixes are possible, so that the program could be maintained until Age Concern comes on-line.We are now engaged in a project to transfer the knowledge encoded in CRYSTALS (and other programs) into a modern software setting - the Age Concern project - in collaboration with Durham. Postal Address; Chem CrystDepartment of ChemistryUniversity of OxfordChemistry Research LaboratoryMansfield RoadOxfordOX1 3TA
Dr David WatkinTelephone: +44 (0) 1865 285019Fax: +44 (0) 1865 285021email: david.watkin@chem.ox.ac.uk

SAFIRE SCIENTIFIC COMPANY

ABOUT Us Established in the year 1979, Safire Scientific Company is a leading manufacturer and exporter of Laboratory Chemicals, Chemical Laboratory Equipment, Laboratory Glassware, Laboratory Grade Chemicals, Glass Apparatus, Laboratory Instruments and Lab Equipments, Textile Glass Spares and Glass moulds for Rubber Industry since the last twenty-five years. We always strive to achieve excellence in every sphere of our operation so that our customer's get superior qulity produts. The company also specializes in manufacturing and export of custom-bound glassware and equipments suitable to the needs of its valuable customers. We have made a huge market share owing to our dedicated team, value products and timely delivery. Safire Scientific Company has been conferred with National Excellence Award for its exceptional performance in scientific field. With our outstanding accomplishments in delivering quality innovations, we have been accredited with international certification of ISO 9001 from TUV Germany. Our products have been Contact Person : N. Shri Manivannan Address : P.B.No: 1115, 93-A (New No: 111), Megricar Road, R.S.Puram Coimbatore, Tamil Nadu - 641002 Phone : + 91-422-2471891/5365444 Mobile : 9842244569 / 9363103326 Fax : + 91-422-2473374 Website : http://safirescientific.tradeget.com/ Other Website : http://www.safirescientific.com honoured by customers for their precision and perfection.uperior quality products.

Reddy'sLab

ABOUT US

At Dr. Reddy's, our aim is to help people lead healthier lives through two parallel objectives: making medicines affordable and accessible in all parts of the world so that as many people as possible benefit from them; and discovering, developing and commercializing innovative treatment options that satisfy unmet medical needs.
Headquartered in India, we are a global pharmaceutical company with a presence in more than 100 countries. We have wholly-owned subsidiaries in the US, UK, Russia, Germany and Brazil; joint ventures in China, South Africa and Australia; representative offices in 16 countries; and third-party distribution set ups in 21 countries. Dr. Reddy’s is the first pharmaceutical company in Asia outside of Japan to be listed on the NYSE.Our strong portfolio of businesses, geographies and products gives us an edge in an increasingly competitive global market and allows us to provide affordable medication to people across the world, regardless of geographic and socio-economic barriers.